Placental and umbilical cord's levels of transforming growth factor-β_1 in pregancy-induced hypertension and the study on its pathogenesis of PIH.

Objective: To investigate the relationship between the expression of transforming growth-β 1(TGF-β 1) in placenta and umbilical cord and the pathogenesis of pregnancy-induced hypertension(PIH). Methods: The study population consisted of 20 normal pregnancy women and 40 women PIH. Placental tissues and umbilical cords were obtained after caesarean. Immunohistochemistry was used toobserve the expression and distribution of TGF-β 1 in placenta tissues and umbilical cords. High resolution pathological image analysis system(HPIAS) was used to determine the quality of TGF-β 1. The pathology changes in placenta tissues and umbilical cords were observed by HE staining. Results: TGF-β 1 could express in syncytiotrophoblast and all layers ofumbilical vessels. The levels of TGF-β 1 expression of placenta on moderate and severe PIH patients were significant higher than that of normal group(P0.05), and the expression of TGF-β 1 in umbilical cord was no significant difference between normal women and PIH patients (P0.05). Nodules of syncytiotrophoblast, fibrinoid necrosis and damage of endometrium were. observed by HE staining. Conclusion: The levels of TGF-β 1 expression in PIH increases obviously and it may be involved in the pathogenesis of PIH.