The progress in diagnosis and treatment of ovarian cancer

The early diagnosis of ovarian cancer has been relied on the classical tumor marker cancer antigen 125 (CA_125),as well as transvaginal ultrasonography (TVS).Recently,the new markers of human epididymis protein 4 (HE_4) and proteomics become very important for monitoring ovarian cancer pathogenesis,treatment,clinical outcome and recurrence.The normative and thoroughness of the initial surgery for ovarian cancer are critical to the proper surgery and chemotherapy.Early ovarian cancer should conduct a comprehensive staging operation.When necessary,the re-staging should be done before chemotherapy.In advanced stage of ovarian cancer,it had better to do cytoreductive surgery,in combination with neoadjuvant chemotherapy.After early diagnosis and standard treatment,the survival rate of ovarian cancer has been increased significantly,however,gynecological oncologist can not ignore the high relapse rate and mortality.