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Synthesis of 2-(4-Chlorophenyl)ethanol

Lirong Yang

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Abstract

2-(4-Chlorophenyl)ethanol(1) was synthesized by esterification and reduction from 2-(4-chlorophenyl)acetic acid(3).The structure was characterized by 1H NMR and MS.The appropriate reaction conditions were as follows: 3 was 30 mmol,ethanol was 120 mmol,n(3)∶n(SOCl2)∶n(NaBH4) was 1.0 ∶0.5 ∶1.6.The yield of 1 was over 95% by esterification at room temperature for 3 h and reduction at 75 ℃ for 5 h.

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2-(4-Chlorophenyl)ethanol(1) was synthesized by esterification and reduction from 2-(4-chlorophenyl)acetic acid(3).The structure was characterized by 1H NMR and MS.The appropriate reaction conditions were as follows: 3 was 30 mmol,ethanol was 120 mmol,n(3)∶n(SOCl2)∶n(NaBH4) was 1.0 ∶0.5 ∶1.6.The yield of 1 was over 95% by esterification at room temperature for 3 h and reduction at 75 ℃ for 5 h.

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Available abstract

2-(4-Chlorophenyl)ethanol(1) was synthesized by esterification and reduction from 2-(4-chlorophenyl)acetic acid(3).The structure was characterized by 1H NMR and MS.The appropriate reaction conditions were as follows: 3 was 30 mmol,ethanol was 120 mmol,n(3)∶n(SOCl2)∶n(NaBH4) was 1.0 ∶0.5 ∶1.6.The yield of 1 was over 95% by esterification at room temperature for 3 h and reduction at 75 ℃ for 5 h.

Key concepts: Chemistry, Ethanol, Yield (engineering), Acetic acid, Proton NMR, Nuclear chemistry, Organic chemistry, Metallurgy

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