Comparison of Single Imaging and Fusion Imaging Technique for Assessing Myocardial Perfusion in Patients of Type 2 Diabetes Mellitus With Coronary Artery Lesions

Objective:To compare the effect of single myocardial perfusion imaging(MPI) and MPI combined with coronary CT angiography(CCTA) on coronary artery lesion diagnosis in patients of type 2 diabetes mellitus(DM) with coronary artery lesions. Methods:A total of 85 diabetic patients with coronary artery disease(CAD) or suspected CAD were examined by adenosine stress/rest MPI and coronary angiography(CAG) within one month,38 of them underwent CCTA with the same SPECT/CT facility.MPI was evaluated by semi quantitative visual interpretation using a 17-segment model.According to CAG and CCTA stan-dard,the coronary condition was defined as normal,mild,intermediate and severe lesions.CAG and CAG/ MPI combination were used to evaluate the effect of coronary lesion diagnosis for MPI and MPI/CCTA fusion imaging.Results:In 85 patients,MPI presented normal/abnormal was 22/63.MPI diagnostic sensitivity,specificity,accuracy,positive and negative prediction rate for coronary lesions were 80.19%,88.59%,85.10%,83.33% and 86.27% respectively;it showed 20(24%) mild lesion cases,12(14%) intermediate lesion cases and 31(36%) severe lesion cases.For 38 patients who underwent CCTA,the diagnostic sensitivity,specificity,accuracy,positive and negative prediction rate by MPI vs.MPI/CCTA were 74.55% vs.96.97%,81.36% vs.91.67%,78.07% vs.94.74%,78.85% vs.94.12% and 77.42% vs.95.65% respectively.MPI/CCTA fusion imaging presented normal 40.35%(46 segment /114 branch),intermediate or more stenosis 59.65%(68 segment /114 branch).Conclusion:MPI/CCTA fusion imaging has been superior to MPI alone for early CAD diagnosis in DM patients with coronary artery lesions.