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Function of VEGF-C and Its Receptor VEGFR-3 on Lymphatic Metastasis of Esophagus Cancer

Sufen Guo

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Abstract

VEGF-C is a member of VEGF family,found to the first growth factor promoting lymphangiogenesis so far,and mainly promotes lymphangiogenesis around tumors and regional lymph node metastasis by binding with its receptor VEGFR-3 specifically on lymphatic endothelial cells.VEGFR-3 is a comparatively special receptor of VEGF-C,playing an important role in the lymphangiogenesis.It is expressed both in the venules and lymphatic vessels in embryo.However,in adulthood,VEGFR-3 is only expressed in the lymphatic endothelium.Thus,it can be applied as a marker differentiating lymphatic from vascular vessels in adult.This articles reviews the structure and function of VEGF-C and its receptor VEGFR-3 and their function on lymphatic metastasis of esophagus cancer.

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What this paper is about

VEGF-C is a member of VEGF family,found to the first growth factor promoting lymphangiogenesis so far,and mainly promotes lymphangiogenesis around tumors and regional lymph node metastasis by binding with its receptor VEGFR-3 specifically on lymphatic endothelial cells.VEGFR-3 is a comparatively special receptor of VEGF-C,playing an important role in the lymphangiogenesis.It is expressed both in the venules and lymphatic vessels in embryo.However,in adulthood,VEGFR-3 is only expressed in the lymphatic endothelium.Thus,it can be applied as a marker differentiating lymphatic from vascular vessels in adult.This articles reviews the structure and function of VEGF-C and its receptor VEGFR-3 and their function on lymphatic metastasis of esophagus cancer.

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Available abstract

VEGF-C is a member of VEGF family,found to the first growth factor promoting lymphangiogenesis so far,and mainly promotes lymphangiogenesis around tumors and regional lymph node metastasis by binding with its receptor VEGFR-3 specifically on lymphatic endothelial cells.VEGFR-3 is a comparatively special receptor of VEGF-C,playing an important role in the lymphangiogenesis.It is expressed both in the venules and lymphatic vessels in embryo.However,in adulthood,VEGFR-3 is only expressed in the lymphatic endothelium.Thus,it can be applied as a marker differentiating lymphatic from vascular vessels in adult.This articles reviews the structure and function of VEGF-C and its receptor VEGFR-3 and their function on lymphatic metastasis of esophagus cancer.

Key concepts: Lymphangiogenesis, Lymphatic system, Lymphatic vessel, Vascular endothelial growth factor C, Lymphatic Endothelium, Cancer research, Metastasis, Pathology

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Function of VEGF-C and Its Receptor VEGFR-3 on Lymphatic Metastasis of Esophagus Cancer — Research Paper | ScholarLens