Effect of Fuzhisan(FZS) on cognitive ability and cholinergic system of Alzheimer′s disease (AD) model mice

Objective To observe the effect of FZS on cognitive ability and cholinergic system in the brain of Alzheimer′s disease (AD) model mice induced by intraventricular Aβ25-35 injection.Methods The AD model mice was established by injected Aβ25-35 to lateral ventricle.The cognitive ability of AD model was detected by water amaze test and shuttle box test.The activity of acetylcholinesterase(AchE) and choline acetyltransferase(ChAT) in the brains were examined by colorimetric method.The acetylcholine(Ach) content was examined by alk hydroxylamine colorimetric method.Results FZS effectively improved cognitive performance,including learning and memory ability of the AD model mice,and not only degraded AchE activity,but also enhanced ChAT activity and Ach content in the AD model mice brain.Conclusions FZS can effectively improve cognitive performance by regulating cholinergic system function in the brain and cure AD.