Expression of P27 and P53 and the correlation between P27 and P53 in epithelial ovarian tumor

Objective To investigate the clinical significance of P27 and P53 in the pathogenesis,development and prognosis of epithelial ovarian tumor,and to explore the correlation between P27 and P53.Methods The expressions of P27 and P53 were detected by immunohistochemisty(SP)in 57 cases of malignant ovarian tumor(malignancy group),18 cases of borderline ovarian epithelial neoplasm(borderline group),25 cases of benign ovarian tumor(benign group)and 20 cases of normal ovarian tissue samples(control group).Results The expression of P27 was gradually reduced in the order of control group,benign group,borderline group and malignancy group,furthermore,the expression of P27 in malignancy group was significantly lower than that in control group and benign group(P0.05).The expression of P27 in malignancy group was not related with patient’s age,pathological type,lymph node metastasis,and there were no significant differences(P0.05).However the expression of P27 in malignancy group was closely correlated with clinical staging and tissue differentiation,and there were significant differences(P0.05).The expression of P53 was not found in control group,however,the expression of P53 in malignancy group was significantly higher than that in control group,benign group and borderline group(P0.05).There was no significant difference in the expression of P53 in malignancy group among patient’s age,pathological type,lymph node metastasis(P0.05),and the expression of P53 in low differentiation group was significantly higher than that in medium and high differentiation group,which at Ⅲ～Ⅳ stage was significantly higher than that at Ⅰ～Ⅱstage(P0.05).The expression of P27 was negatively correlated with that of 53(r=-0.397,P0.05).Conclusion The decrease of P27 expression and abnormal expression of P53 protein may play a certain promotive role in the development of epithelial ovarian cancer,furthermore,P27 protein may be the sign of malignant degree and pathological classification of epithelial ovarian tumor,which prognosticates bad prognosis.