Expression and Clinical Value of CD8~+ CD28~- Treg cell in Patients with Allergic Purpura

Objective To research expression and clinical value of CD4+T cell,CD8+T cell,CD8+CD28-Treg cell in patients with allergic purpura. Methods 2ml peripheral blood was drawn from 78 allergic purpura patients respectively. Heparin was added to the drawn peripheral blood. CD4+T cell,CD8+T cell,CD8+CD28-Treg cell in the blood were detected by flow cytometry(FCM). These patients were treated with Histamine drugs,Vitamin C,Rutin tablets and Calcium supplements. In order to relieve symptoms and hemorrhage,sugar cortical hormone and immune globulin were used to treat patients with severe kidney disease symptoms. Two weeks later,peripheral blood sample was collected again and the expression levels of CD4+T cell,CD8+T cell and CD8+CD28-Treg cell in the peripheral blood were detected by FCM. Result After allergic purpurapatients were treated,CD4+cells in peripheral blood increased,and CD8+T cells in peripheral blood decreased. CD8+CD28-Treg cells were obviously increased. Conclusion CD8+CD28-Treg cells in peripheral blood have instructive meaning for the diagnosis and treatment of allergic purpura.