Application of AMACR,p63 and 34βE12 in Diagnosis of Prostatic Disease

Objective To investigate the expression of AMACR,p63 and 34βE12 in prostate disease and the significance in the diagnosis of the disease.Methods Immunohistochemistry was used to detect the expression of AMACR、p63 and 34βE12 in 37 cases of prostate adenocarcinoma,14 cases of high-grade prostatic intraepithelial neoplasia(HGPIN) and 25 cases of benign prostate hyperplasia(BPH).Results The positive rate of AMACR was 100.0% in prostate adenocarcinoma tissues,with strong cytoplasmic granular staining and the positive rates of AMACR in HGPIN and BPH tissues were 64.29% and 0,respectively.The expression of AMACR was significantly different between the prostate adenocarcinoma,HGPIN and BPH (P0.01).The positive rates of p63 and 34βE12 in prostate adenocarcinoma,HGPIN and BPH were 0,71.43% and 100.00%,respectively.There were significant differences of these values between three groups (P0.01).Conclusion AMACR is a sensitive and specific marker for prostate adenocarcinomam and immunohistochemistry study using a combination of AMACR,p63 and 34βE12 may be of greater benefit in aiding the differential diagnoses of prostatic disease.