Paclitaxel plus low dose of cisplatin and low dose of 5-fluorouracil continuous infusion combination chemo-theay in the treatment of advanced gastric carcinoma

Objective:To evaluate the efficacy and toxicity of paclitaxel and low dose of cisplatin plus low dose of 5-fluorouracil continuous infusion combination chemotheay in the treatment of advanced gastric carcinoma.Methods:Thirty-five patients, including 14 cardiac cancer patients and 21 gastric body cancer patients, were treated with the following regimen, administered every 21 days, paclitaxel 90mg/m2 by i.v. on d_1, d_8, 5-FU 250mg/m2 by 24h c.i.v. for 12 days and cisplatin 6mg/(m2·d) by i.v for continous 5 days with 2 days interval within 12 days. All the patients received over two cycles of chemotherapy, median 3.06 cycles.Results:The overall response rate (CR+PR) was 57.1%. TCR(CR+PR+SD) was 85.7%. The median TTP was 9 months(1～32 months). The MST was 13 months(2～35 months). The major toxicity of this treatment were myelosuppression, nausea/vomiting and mucositis.Conclusion:Paclitaxel plus low dose of cisplatin and low dose of 5-fluorouracil continuous infusion combination chemotherapy in the treatment of advanced gastric carcinoma is effective and tolerable. It is worth studying in the future.