The diagnostic value of the serum cystatin C and urin trace protein on the damage in early diabetic nephropathy

Objective To investigate serum cystatin C,urin of albumin (mAlb),α1-microglobulin (α1-MG) and β2- microglobulin (β2-MG) level on the damage in early diabetic nephropathy.Methods 72 patients with early diabetic nephropathy were selected in our hospital from October 2009 to June 2012 as the observation group,while 72 healthy subjects were selected as the control group.Serum cystatin C of the two groups were examined by adoption of latex en- hanced turbidimetry and take morning urine to examine the mAlb,α1-MG and β2-MG of the two groups.The detection of indicators and the positive rate of the two groups were observed.Results Serum cystatin C,mAlb,α1-MG and β2-MG of the observation group were significantly higher than that of the control group,there was statistical difference ( P0.05). The positive rate of Cys-C of the observation group was 77.8% (56/72),the positive rate of mAlb was 68.1% (49/72),the positive rate of α1-MG was 48.6% (35/72),the positive rate of β2-MG was 54.2% (39/72),the positive rate of the four markers was 90.3% (65/72),the combined detection rate of the damage in early diabetic nephropathy was significantly higher than that of detection alone,there was statistical difference ( P0.05).Conclusion Serum cystatin C and various levels of the urine protein can be used as markers of early renal damage,but the combination of the many markers can significantly improve the detection rate of the damage in early diabetic nephropathy.It is worth to be popularized in clinical application.