Clinical analysis of the cerebral ischemic disease related to internal carotid artery stenosis

Objective To study the clinical features and mechanisms of the cerebral ischemic disease related to internal carotid artery stenosis.Methods The clinical performance,TCD data and the appearance of Willis' circle of 111 patients with internal carotid artery stenosis confirmed by CTA were analyzed retrospectively.Results The occurrence rate of cerebral infarction in slight stenosis groups was 14.7%,moderate stenosis group was 30.6% and severe group was 46.3%. Statistical differences of cerebral infarction were found among the three groups.(P0.05).The occurrence rate of collateral circulation in slight stenosis was 14.7%,moderate stenosis group was 30.6%,severe group was 78.0%.Statistical differences of cerebral infarction were found among the three groups.(P0.05).In sereve stenosis patients,the occurrence rate of cerebral infarction in type Ⅰ Willis' circle was 11.1%,significantly lower than other groups.(P0.01).In sereve stenosis patients,the occurrence rate of cerebral infarction in the secondary collateral pathways group was 80.0%,significantly higher than other groups.(P0.01)Conclusion The degree of internal carotid artery stenosis,the appearance of Willis ' circle and the pathways of collateral circulation are closely associated with clinical prognosis.