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The effect of HBO treatment on platelet membrane glycoprotein CD63,PAC-I and CD62p in patients with acute carbon monoxide poisoning

Huan Ge

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Abstract

Objective To study the effect of HBO treatment on platelet membrane glycoprotein in patients with acute carbon monoxide poisoning in order to instruct the anti-platelet therapy of ACOP . Methods Subjects were divided into ACOP group , HBO group and normal control group.15 patients in the ACOP group who received 10 days therapy of the HBO formed the HBO group.Blood was drawn insistently from patients in the ACOP group when they arrived at hospital.Drawn from patients in the HBO group at 8 AM after an overnight fast on the 3rd, the 7th, the 10th day after acute carbon monoxide poisoning;that was drawn from the normal control group at 8 AM after an overnight fast. The positive percentage of CD63, PAC-Ⅰ and CD62p were measured by the flow cytometry (FCM). Analysis of t test, variance(ANOVA) and Q test were applied to analyse the expressions of platelet membrane glycoprotein CD63, PAC-Ⅰ and CD62p. Results The expressions of platelet membrane glycoprotein CD63, PAC-Ⅰ and CD62p of the ACOP group were much higher than these of the normal control group(P0.01). After the treatment of HBO,the expressions of CD63 and CD62p decreased, the expression of PAC-Ⅰ showed a downward trend. Conclusions The expression of CD63, PAC-Ⅰ and CD62p on the platelet membrane significantly increased after acute carbon monoxide poisoning. According to this study, the expressions of PAC-Ⅰ and CD63 maintained a high level in the acute period. It indicates that the inhibition of platelet activation is needed and should be applied for a period of time after the remission of clinical symptoms.

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Objective To study the effect of HBO treatment on platelet membrane glycoprotein in patients with acute carbon monoxide poisoning in order to instruct the anti-platelet therapy of ACOP . Methods Subjects were divided into ACOP group , HBO group and normal control group.15 patients in the ACOP group who received 10 days therapy of the HBO formed the HBO group.Blood was drawn insistently from patients in the ACOP group when they arrived at hospital.Drawn from patients in the HBO group at 8 AM after an overnight fast on the 3rd, the 7th, the 10th day after acute carbon monoxide poisoning;that was drawn from the normal control group at 8 AM after an overnight fast. The positive percentage of CD63, PAC-Ⅰ and CD62p were measured by the flow cytometry (FCM). Analysis of t test, variance(ANOVA) and Q test were applied to analyse the expressions of platelet membrane glycoprotein CD63, PAC-Ⅰ and CD62p. Results The expressions of platelet membrane glycoprotein CD63, PAC-Ⅰ and CD62p of the ACOP group were much higher than these of the normal control group(P0.01). After the treatment of HBO,the expressions of CD63 and CD62p decreased, the expression of PAC-Ⅰ showed a downward trend. Conclusions The expression of CD63, PAC-Ⅰ and CD62p on the platelet membrane significantly increased after acute carbon monoxide poisoning. According to this study, the expressions of PAC-Ⅰ and CD63 maintained a high level in the acute period. It indicates that the inhibition of platelet activation is needed and should be applied for a period of time after the remission of clinical symptoms.

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Available abstract

Objective To study the effect of HBO treatment on platelet membrane glycoprotein in patients with acute carbon monoxide poisoning in order to instruct the anti-platelet therapy of ACOP . Methods Subjects were divided into ACOP group , HBO group and normal control group.15 patients in the ACOP group who received 10 days therapy of the HBO formed the HBO group.Blood was drawn insistently from patients in the ACOP group when they arrived at hospital.Drawn from patients in the HBO group at 8 AM after an overnight fast on the 3rd, the 7th, the 10th day after acute carbon monoxide poisoning;that was drawn from the normal control group at 8 AM after an overnight fast. The positive percentage of CD63, PAC-Ⅰ and CD62p were measured by the flow cytometry (FCM). Analysis of t test, variance(ANOVA) and Q test were applied to analyse the expressions of platelet membrane glycoprotein CD63, PAC-Ⅰ and CD62p. Results The expressions of platelet membrane glycoprotein CD63, PAC-Ⅰ and CD62p of the ACOP group were much higher than these of the normal control group(P0.01). After the treatment of HBO,the expressions of CD63 and CD62p decreased, the expression of PAC-Ⅰ showed a downward trend. Conclusions The expression of CD63, PAC-Ⅰ and CD62p on the platelet membrane significantly increased after acute carbon monoxide poisoning. According to this study, the expressions of PAC-Ⅰ and CD63 maintained a high level in the acute period. It indicates that the inhibition of platelet activation is needed and should be applied for a period of time after the remission of clinical symptoms.

Key concepts: CD63, Platelet, Platelet membrane glycoprotein, Carbon monoxide poisoning, Platelet activation, CO poisoning, Chemistry, Flow cytometry

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The effect of HBO treatment on platelet membrane glycoprotein CD63,PAC-I and CD62p in patients with acute carbon monoxide poisoning — Research Paper | ScholarLens