ApoE and ApoE Knockout Mice

ApoE is an important component of plasma lipoproteins,and plays significant roles in lipoprotein metabolism.The absence or mutation of apoE may give rise to abnormal metabolism in vivo and dysfunction of organs,and then lead to a series of diseases and complications.Since the generation of apoE knockout mice,they have offered a wonderful base to study the functions of apoE and its roles in various related disease.Recently,the apoE knockout mice have been regarded as one of most popular animal models in experimental atherosclerosis research.