2011•Unpublished venueRequires access

The molecular mechanism of the blast crisis of chronic myelogenous leukemia

Wenli Feng

Abstract

Chronic myelogenous leukemia(CML) is a malignant myeloproliferative disease derived from hematopoietic stem cells harbored with t(9;22)(q34;q11) translocation.The fatality of blast crisis of CML is similar to acute myelogenous leukemia.Recent literatures were retrospectively analyzed in this article to further understand the molecular mechanism of development of blast crisis,and discover new research clues.

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Key concepts: Blast Crisis, Chronic myelogenous leukemia, Leukemia, Mechanism (biology), Chromosomal translocation, Haematopoiesis, Medicine, Disease