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Characteristics of abnormal immunophenotype and clinical significance in acute myelocytic leukemia

Haibin Dai

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Abstract

Objective To investigate the characteristics of abnormal immunophenotype and clinical significance in acute myelocytic leukemia(AML).Methods Immunophenotyping of 38 adults with AML was performed by multi-color flow cytometry analysis.Results Myeloid-associated specific antigen of AML patients from high to low were: CD33,CD13,cMPO,CD117,CD11b.Cross-lineage antigen expression from high to low were: CD19,cCD79a,CD7 and so on.CD19+,CD7+ patients had lower complete remission(CR) rate than CD19-,CD7-patients(P0.05).A proportion of patients had early nonspecific antigen expression.They were CD34,HLA-DR,and CD38.The CR rates were not statistically significant(P0.05) between patients with CD34+,CD56+ and those with CD34-,CD56-.Conclusion CD33,CD13,CD117,and cMPO are common and sensitive myeloid associated antigens.The patients with CD19+ or CD7+ have lower CR rate than negative patients.

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Objective To investigate the characteristics of abnormal immunophenotype and clinical significance in acute myelocytic leukemia(AML).Methods Immunophenotyping of 38 adults with AML was performed by multi-color flow cytometry analysis.Results Myeloid-associated specific antigen of AML patients from high to low were: CD33,CD13,cMPO,CD117,CD11b.Cross-lineage antigen expression from high to low were: CD19,cCD79a,CD7 and so on.CD19+,CD7+ patients had lower complete remission(CR) rate than CD19-,CD7-patients(P0.05).A proportion of patients had early nonspecific antigen expression.They were CD34,HLA-DR,and CD38.The CR rates were not statistically significant(P0.05) between patients with CD34+,CD56+ and those with CD34-,CD56-.Conclusion CD33,CD13,CD117,and cMPO are common and sensitive myeloid associated antigens.The patients with CD19+ or CD7+ have lower CR rate than negative patients.

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Available abstract

Objective To investigate the characteristics of abnormal immunophenotype and clinical significance in acute myelocytic leukemia(AML).Methods Immunophenotyping of 38 adults with AML was performed by multi-color flow cytometry analysis.Results Myeloid-associated specific antigen of AML patients from high to low were: CD33,CD13,cMPO,CD117,CD11b.Cross-lineage antigen expression from high to low were: CD19,cCD79a,CD7 and so on.CD19+,CD7+ patients had lower complete remission(CR) rate than CD19-,CD7-patients(P0.05).A proportion of patients had early nonspecific antigen expression.They were CD34,HLA-DR,and CD38.The CR rates were not statistically significant(P0.05) between patients with CD34+,CD56+ and those with CD34-,CD56-.Conclusion CD33,CD13,CD117,and cMPO are common and sensitive myeloid associated antigens.The patients with CD19+ or CD7+ have lower CR rate than negative patients.

Key concepts: CD33, Immunophenotyping, CD117, CD34, Medicine, Myeloid leukemia, Clinical significance, Antigen

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