Protective Effects of Compound Xuejie Capsule on Focal Cerebral Ischemia-Reperfusion Injury in Rats

Objective To explore the effects of Compound Xuejie Capsule(CXJC) on focal cerebral ischemia-reperfusion injury in rats.Methods 40 male Sprague-Dawley rats were randomly divided into five groups: sham group,ischemia-reperfusion group,CXJC groups of low dose(0.14 g·kg~(-1)),middle dose(0.56 g·kg~(-1)) and high dose(1.12 g·kg~(-1)).There were 8 animals in each group.The models of middle cerebral artery occlusion(MCAO) were established in rats.At 24h after MCAO,the extent of neurological deficit by scores grading on a scale of 0～4,cerebral edema with wet/dry weighing recorded and the size of cerebral infarction by TTC staining technique were determined.Results CXJC 0.14,0.56 and 1.12 g·kg~(-1) were found decreasing neurological deficit scores at 3h after ischemia-reperfusion(P0.01),the scores at 6h and 24h in CXJC 0.56 g·kg~(-1) group was still lower than that of the ischemia-reperfusion group(P0.05).CXJC of three doses also decreased both infarction volumes and cerebral water contents(P0.01 or P0.05).Conclusion CXJC has protective effects on cerebral ischemic-reperfusion injury in rats.