Therapeutic Effect of Salidroside on Paraquat-induced Acute Lung Injury in Rats

Objective:To investigate the mechanism of salidroside(SDS) in the treatment of paraquat-induced acute lung injury(ALI) in rats.Methods:Thirty-six male SD rats were randomly divided into three groups:control group(NS group),paraquat group(PQ group),SDS treatment group(SDS group).The ALI model induced by PQ poisoning was produced by intraperitoneal injection PQ solution,and the rats in NS group were given normal saline solution with the same volume.One hour after the administration,rats in SDS group were given SDS,and PQ group were given normal saline solution with the same volume.Twenty-four hours later,the wet-to-dry(W/D) weight ratios of the lung and the content of tumor necrosis factor-α(TNF-α) were measured,and the pathology of lung tissue by HE staining was also observed.Results:Histological study showed congestion,edema and sequestration of inflammatory cells in the lung tissues in PQ group,but the lung injury was significantly alleviated in SDS group.Compared to NS group,the content of TNF-α was increased greatly(P0.05) in the lung tissues,and the W/D ratio was significantly increased in PQ group.SDS treatment inhibited all these increased parameters(P0.05).Conclusion: SDS has therapeutic effect on the ALI induced by PQ poisoning and the mechanism may be associated with the reduction of the radical injury.