Clinical Efficacy of Trazodone and Cognitive Behavioral Therapy on Post-traumatic Stress Disorder Soldiers

Objective To investigate the clinical effect of trazodone combined with cognitive behavioral therapy(CBT) or trazodone alone on post-traumatic stress disorder(PTSD).Methods 48 soldiers with PTSD treated in our hospital were randomly divided into two groups:study group(24 patients,trazodone plus CBT) and control group(24 cases,trazodone therapy alone).Prior to treatment,at the end of the 2nd and 4th week,Brief Psychiatric Rating Scale(BPRS),Hamilton Depression Scale(HAMD) and Hamilton Anxiety Scale(HAMA) were used to assess the clinical efficacy and side effects.Results After two and four weeks of treatment,BPRS,HAMD and HAMA scores of the two groups significantly declined(P 0.01),especially in the study group(P 0.05).The effective rate of study group was 87.5%,significantly higher than 70.8% of control group(P 0.05).The side effects in the two groups were not significantly different(P 0.05).Conclusion Trazodone combination with CBT is more effective than trazodone alone for PTSD patients.