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2008•Zhongguo fushe weishengRequires access

Adaptive Response of EL-4 Lymphoma Cell Cycle Progression Induced by Low Dose Radiation in Vitro.

Shuchun Liu, Wang Zhicheng, Liu Yang, Xuan Zhang, Gong Shouliang

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Abstract

Objective To explore the adaptive response of EL-4 cycle progression induced by low dose radiation in vitro.Methods EL-4 lymphoma cells were irradiated with the inductive doses(D1:25-200 mGy,12.5 mGy/min)and the challenging dose(D2:0.5-3.0 Gy,287 mGy/min).The interval time between D1 and D2 was 6 h.The cell percentages of each cell cycle phase were measured with flow cytometry.Results The cell percentages of G0/G1 phase in the D1 + D2 group with25-100 mGy(D1)and 1.5 Gy(D2)or 75 mGy(D1)and 25-200 mGy(D2)were invaribly lower than those in the D2 group,while the cell percentages of S phase increased significantly(P0.05,P0.01 or P0.001).Conclusion The results suggest that EL-4 lymphoma cells were irradiated with 25-100 mGy at 6h before 1.0-2.0 Gy exposure.The low-dose radiation could induce the adaptive response of the cell cycle progression in vitro.

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Objective To explore the adaptive response of EL-4 cycle progression induced by low dose radiation in vitro.Methods EL-4 lymphoma cells were irradiated with the inductive doses(D1:25-200 mGy,12.5 mGy/min)and the challenging dose(D2:0.5-3.0 Gy,287 mGy/min).The interval time between D1 and D2 was 6 h.The cell percentages of each cell cycle phase were measured with flow cytometry.Results The cell percentages of G0/G1 phase in the D1 + D2 group with25-100 mGy(D1)and 1.5 Gy(D2)or 75 mGy(D1)and 25-200 mGy(D2)were invaribly lower than those in the D2 group,while the cell percentages of S phase increased significantly(P0.05,P0.01 or P0.001).Conclusion The results suggest that EL-4 lymphoma cells were irradiated with 25-100 mGy at 6h before 1.0-2.0 Gy exposure.The low-dose radiation could induce the adaptive response of the cell cycle progression in vitro.

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Available abstract

Objective To explore the adaptive response of EL-4 cycle progression induced by low dose radiation in vitro.Methods EL-4 lymphoma cells were irradiated with the inductive doses(D1:25-200 mGy,12.5 mGy/min)and the challenging dose(D2:0.5-3.0 Gy,287 mGy/min).The interval time between D1 and D2 was 6 h.The cell percentages of each cell cycle phase were measured with flow cytometry.Results The cell percentages of G0/G1 phase in the D1 + D2 group with25-100 mGy(D1)and 1.5 Gy(D2)or 75 mGy(D1)and 25-200 mGy(D2)were invaribly lower than those in the D2 group,while the cell percentages of S phase increased significantly(P0.05,P0.01 or P0.001).Conclusion The results suggest that EL-4 lymphoma cells were irradiated with 25-100 mGy at 6h before 1.0-2.0 Gy exposure.The low-dose radiation could induce the adaptive response of the cell cycle progression in vitro.

Key concepts: Nuclear medicine, Cell cycle, Lymphoma, Irradiation, In vitro, Flow cytometry, Cell cycle progression, Medicine

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