Renoprotective effects of losartan combined with captopril in spontaneo usly hypertensive rats

OBJECTIVE To observe the effects of losartan and c aptopril on renal structure and function in spontaneously hypertensive rats(SHR) .METHODS Thirty SHRs were gorged with losartan (30 mg·kg -1 ·d -1 ), captopril (100 mg·kg -1 ·d -1 ),losartan (15 mg·k g -1 ·d -1 ) + captopril (50 mg·kg -1 ·d -1 ) or water respec tively for 15 weeks in the treating and control groups.The blood pressure and pr oteinuria were assessed, the levels of angiotensin Ⅱ(AngⅡ) and transforming gr owth factor(TGF)β 1 were detected, and renal tissues were examined routinely b y optical and electron microscopy respectively.RESULTS The e xcretion of proteinuria was significantly decreased in the treating groups compa red with the control group.There was a decrease TGFβ 1 and collagen Ⅳ deposit ion in the treatment group, and further lower in losartan + captopril group.Losa rtan and captopril attenuated the injuries of small arteries.CONCLUSI ON The combination of losartan with captopril may attenuate renal damag e,they had synergistic action when used together.