The Study of Midazolam for Neonatal Convulsiens Status Epileptieus

Objective:To study the efficacy of midazolam and sodium phenobarbital in treating neonatal convulsiens status epileptieus.Methods:Study comprised 72 newborns with neonatal convulsiens status epileptieus,they were divided randomly into 2 groups with 36 cases in each.The treatment group was,firstly,given a charge of midazolam of 0.1～0.3 mg/kg once.After a quarter of an hour,a maintenance dose of 1.0 μg/(kg·min) was added,and then a dose of 1.0 μg/(kg·min) was added every 15 minutes until the convulsion stopped.As a contol,36 cases were given the sodium phenobarbital 10 mg/kg once,after half of an hour,a dose of 10 mg/kg was added if the convulsion can't stopped.The time of convulsiens status epileptieuss control were compared between the two groups.Results:The treatment efficiency of treatment group was 83.0%,and was 67.0% of control group.The convulsions control time was(22±15.2) minutes in treatment group,and was(31±16.3) minutes in control group.Efficacy of the treatment group was better than the control group(P0.05).Conclusions:Midazolam is fast and effective in treating neonatal convulsiens status epileptieus.