2003•Progress in Veterinary MedicineRequires access
Effect of Mitochondria on Apoptosis
Jiang Guo
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Abstract
Apoptosis, which is the basically physiological mechanism,is important on renewing the normal cells and eliminating the abnormal cells for multicytoorganism. Mitochondria, which is one of organelles those have supplied energy for creatures' kinds of activation, takes part in apoptosis and is served as the centre of apoptotic regulation. This has been proved in study of cytokine, macrophage, neurocyte, tumor. Apoptosis inducted by NO and Ca 2+ is also completed through the passage of mitochondria. Many mechanisms, which regulated by Caspase, Cyt c,mitochondrial transmembrane potential, and gene Bcl 2 family etc, have acquired content results. However, the passage that mitochondria has taken part in apoptosis is not the only one and further exploration is needed.Relations of mitochondria and apoptosis in the recent years were discussed