Renal functional assessment of hydronephrotic kidney of rabbit with MSCT perfusion imaging

Objective To approach the value of MSCT perfusion imaging in assessment of renal function of unilateral hydronephrotic kidney induced by partial ureteral obstruction.Methods Thirty healthy adult male rabbits were involved in the study.Six were selected randomly as controls,the other 24 were divided into 4 groups of hydronephrotic kidney(each n=6).All animals underwent MSCT perfusion scanning and SPECT examination at 1,3,5 and 7 weeks after obstruction.After examination,hydronephrotic kidneys were microscopically examined.Results ①After obstruction,BF and BV of renal cortex and medulla gradually decreased,and there were difference between control group and the other 4 groups(P0.05).Changes of BF and BV value was coincident with the results of SPECT examination.No difference of MTT and P value of renal cortex and medulla was found among control group,1 and 3 week group,but between 5 and 7 week group.②Histologically,renal pelvis and renal tubules dilated with some atrophic renal tubules.Intertubular distance widened because of interstitial fibrosis.The changes mentioned above became more serious as time went on.Conclusion MSCT perfusion imaging provides a novel approach for functional examination of hydronephrotic kidney.BF and BV value in obstructive renal cortex and medulla decrease continuously,and changes of MTT and P value are probably relative to the fibrotic degree of hydronephrotic kidney.