ScholarLens Back to search
2009•Chinese Journal of General PracticeRequires access

Effect of Combination of OK-432 and Cisplatin on Malignant Pleural Effusion

Lixu Wang

Open publisher page 0 citations

Abstract

Objective To explore curative effect of combination of OK-432 and cisplatin in treatment of malignant pleural effusion.Methods 49 patients with malignant pleural effusion were divided into therapy group and control group randomly.26 patients were treated with OK-432 and cisplatin by intrapleural injection in treatment group.23 patients were treated with cisplatin only by intrapleural injection in control group.The changes in volume of pleural effusion and treatment effects were observed in two groups.Results The effective rate in treatment group and control group were 84.6% and 52.2% respectively(P0.05).The side effects of treatment group were fever,chest ache,arrest of bone marrow and digestive tract reaction,but there was no obvious difference between the two groups(P0.05).Conclusion The intrapleural injection with OK-432 and cisplatin is simple and effective in treatment of malignant pleural effusion,and it is better than that only cisplatin.

About this research paper

What this paper is about

Objective To explore curative effect of combination of OK-432 and cisplatin in treatment of malignant pleural effusion.Methods 49 patients with malignant pleural effusion were divided into therapy group and control group randomly.26 patients were treated with OK-432 and cisplatin by intrapleural injection in treatment group.23 patients were treated with cisplatin only by intrapleural injection in control group.The changes in volume of pleural effusion and treatment effects were observed in two groups.Results The effective rate in treatment group and control group were 84.6% and 52.2% respectively(P0.05).The side effects of treatment group were fever,chest ache,arrest of bone marrow and digestive tract reaction,but there was no obvious difference between the two groups(P0.05).Conclusion The intrapleural injection with OK-432 and cisplatin is simple and effective in treatment of malignant pleural effusion,and it is better than that only cisplatin.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To explore curative effect of combination of OK-432 and cisplatin in treatment of malignant pleural effusion.Methods 49 patients with malignant pleural effusion were divided into therapy group and control group randomly.26 patients were treated with OK-432 and cisplatin by intrapleural injection in treatment group.23 patients were treated with cisplatin only by intrapleural injection in control group.The changes in volume of pleural effusion and treatment effects were observed in two groups.Results The effective rate in treatment group and control group were 84.6% and 52.2% respectively(P0.05).The side effects of treatment group were fever,chest ache,arrest of bone marrow and digestive tract reaction,but there was no obvious difference between the two groups(P0.05).Conclusion The intrapleural injection with OK-432 and cisplatin is simple and effective in treatment of malignant pleural effusion,and it is better than that only cisplatin.

Key concepts: Medicine, Cisplatin, Malignant pleural effusion, Pleural effusion, Effusion, Bone marrow suppression, Surgery, Gastroenterology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effect of Combination of OK-432 and Cisplatin on Malignant Pleural Effusion — Research Paper | ScholarLens