Effects of resveratrol on learning and memory ability of pentylenetetrazole-kindled rats

Objective To study the effects of resveratrol(Res) on spatial learning and memory ability of pentylenetetrazole(PTZ)-kindled model.Methods Chronic PTZ-kindling model was established by injecting PTZ intraperitoneally.After kindling models were established,the Res were applied intragastrically at a dose of 15 mg/kg once a day for 10 d.The seizure latency and onset time were observed and recorded.Spatial learning and memory ability was evaluated by Morris water maze.Results After continuous dosing for 28 d,18 rats were reaching the Racine kindling standard.Rats seizures latent period in the Res group was significantly prolonged,and its duration was significantly shorter than those of the epilepsy model group and the dimethylsulfoxide(DMSO) group with statistically significant difference(P0.05).Place navigation test:at 1 d and 2 d,there was no significant difference in the escape latencies of four groups,while at 3 d,4 d,and 5 d,the escape latencies of epilepsy group and DMSO group were significantly longer compared to normal control group(P0.05).The escape latencies of Res group was significantly lower than those of the epilepsy model group and the DMSO group with statistically significant difference(P0.05).Spatial probe test:length of stay in the quadrant of the original site and the number of crossing times through the original site which removed in epilepsy model group and DMSO group were decreased obviously compared with that of normal group,while they were reduced compared with the Res intervention group with statistically significant difference(P0.05).Conclusion The resveratrol plays a role in anti-epileptic,which also might improve the spatial learning and memory ability of PTZ-kindling model.