2003•Journal of Clinical CardiologyRequires access

Clinical study on oxidative stress in the patients with hyperhomocysteinemia

Jie Niu

Abstract

Objective:To evalutate the possible role of hyperhomocysteine (Hcy) in inducing oxidative stress.Methods:Plasma malondialdehyde (MDA) and extracellular superoxide dismutase (SOD) were measured in all subjects by gas chromatography-mass spectrometry and xanthine oxidase method, respectively. Plasma Hcy was determined by HPLC.Results:Plasma MDA were significantly higher in patients with hyperhomocysteinemia than that in controls (P 0.05). Plasma SOD were lower in patients with hyperhomocysteinemia.Conclusion:Our data suggested that elevated plasma homocysteine promote oxidative stress in human body.

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Key concepts: Hyperhomocysteinemia, Malondialdehyde, Oxidative stress, Xanthine oxidase, Homocysteine, Superoxide dismutase, Medicine, Internal medicine