ScholarLens Back to search
2004•Journal of Hubei InstituteRequires access

Research on Changes of Diabetic Rats Hippocampus Somatostatin mRNA and Cognition Ability

Wu Yang

Open publisher page 0 citations

Abstract

Objective To investigate the ralationship between diabetes and somatostatin(SOM).Methods We established a streptozocin-induced diabetic rats model and stutied the changes of SOM mRNA in hippocampi of diabetic and normal rats by using in situ hybridication and computer image analysis.We studied the machanism of chronic diabetes encephalopathy by observing the changes of somatoostatin mRNA in the hippocampus of diabetic rats was.Results The number,light density and average area of positive cells in dentate gyrus area of hippocampus in diabetes model were reduced significantly as compared with normal rats (P0 01).Conclusion A decline in SOM mRNA expression may play a role in chronic diabetes encephalopathy.

About this research paper

What this paper is about

Objective To investigate the ralationship between diabetes and somatostatin(SOM).Methods We established a streptozocin-induced diabetic rats model and stutied the changes of SOM mRNA in hippocampi of diabetic and normal rats by using in situ hybridication and computer image analysis.We studied the machanism of chronic diabetes encephalopathy by observing the changes of somatoostatin mRNA in the hippocampus of diabetic rats was.Results The number,light density and average area of positive cells in dentate gyrus area of hippocampus in diabetes model were reduced significantly as compared with normal rats (P0 01).Conclusion A decline in SOM mRNA expression may play a role in chronic diabetes encephalopathy.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To investigate the ralationship between diabetes and somatostatin(SOM).Methods We established a streptozocin-induced diabetic rats model and stutied the changes of SOM mRNA in hippocampi of diabetic and normal rats by using in situ hybridication and computer image analysis.We studied the machanism of chronic diabetes encephalopathy by observing the changes of somatoostatin mRNA in the hippocampus of diabetic rats was.Results The number,light density and average area of positive cells in dentate gyrus area of hippocampus in diabetes model were reduced significantly as compared with normal rats (P0 01).Conclusion A decline in SOM mRNA expression may play a role in chronic diabetes encephalopathy.

Key concepts: Hippocampus, Dentate gyrus, Diabetes mellitus, Streptozocin, Somatostatin, Endocrinology, Internal medicine, Medicine

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Research on Changes of Diabetic Rats Hippocampus Somatostatin mRNA and Cognition Ability — Research Paper | ScholarLens