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2006•Journal of Shijiazhuang UniversityRequires access

Spectrophotometric Determination of Vitamin B1 in Medicaments Using Iron(II)-phenanthroline System

Qihong Cai

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Abstract

A simple and sensitive method for the spectrophotometric determination of vitamin B1 is described based on the redox-complexation reaction between Fe(Ⅲ) and vitamin B1.The resulting Fe(Ⅱ) reacts with phenanthroline to form the orange-red coloured ferrionchelate complex.The equation A=0.012 9C + 0.022 7 and its relative coefficient r is 0.998 8.Beer's law is obeyed in the range of 0～60.0 μg·mL-1 of VB1.The detection limit of 0.36 μ g·mL-1 and recovery is between 94.5% and 99.5%.The method has been used to determine VB1 in tablets and injection with satisfactory effects compared with pharmacopoeia method.

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What this paper is about

A simple and sensitive method for the spectrophotometric determination of vitamin B1 is described based on the redox-complexation reaction between Fe(Ⅲ) and vitamin B1.The resulting Fe(Ⅱ) reacts with phenanthroline to form the orange-red coloured ferrionchelate complex.The equation A=0.012 9C + 0.022 7 and its relative coefficient r is 0.998 8.Beer's law is obeyed in the range of 0～60.0 μg·mL-1 of VB1.The detection limit of 0.36 μ g·mL-1 and recovery is between 94.5% and 99.5%.The method has been used to determine VB1 in tablets and injection with satisfactory effects compared with pharmacopoeia method.

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Available abstract

A simple and sensitive method for the spectrophotometric determination of vitamin B1 is described based on the redox-complexation reaction between Fe(Ⅲ) and vitamin B1.The resulting Fe(Ⅱ) reacts with phenanthroline to form the orange-red coloured ferrionchelate complex.The equation A=0.012 9C + 0.022 7 and its relative coefficient r is 0.998 8.Beer's law is obeyed in the range of 0～60.0 μg·mL-1 of VB1.The detection limit of 0.36 μ g·mL-1 and recovery is between 94.5% and 99.5%.The method has been used to determine VB1 in tablets and injection with satisfactory effects compared with pharmacopoeia method.

Key concepts: Phenanthroline, Chemistry, Detection limit, Chromatography, Vitamin, Orange (colour), Spectrophotometry, Redox

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