2013•Zhongguo quanke yixueRequires access
Impact of Alanyl-glutamine on Immune Function of Postoperative Non-small Cell Lung Cancer Patients
Daqian Sun
Open publisher page 0 citations
Abstract
Objective To investigate the impact of the Alanyl-glutamine(Ala-Glu) injection on the post-operative immune function of patients with NSCLC.Methods Seventy patients undergoing NSCLC surgery in our hospital between February and June 2011 were randomly divided into an experimental group(n=35) and a control group(n=35) by random number table.All the patients were served with the same amount of food after surgery.Patients in the experimental group were given 0.5 g·kg-1·d-1 Ala-Glu injection during day 1~day 7 after surgery.The IgG,IgA,IgM,C3,C4,CD3+,CD4+,CD8+,and CD4+/CD8+ were observed on day 1 before surgery,and day 4 and 8 after surgery.Results The IgG,IgA,IgM and C4 of the control group,and the IgG,IgA,IgM,C3,and C4 of the experimental group were significantly different on day 1 before surgery,day 4 and day 8 after surgery(P0.05).The IgG,IgA,IgM,and C4 of both groups were significantly different on day 1 before surgery and day 4 after surgery(P0.05).The IgG,IgA,IgM,C3,and C4 on neither day 1 before surgery nor day 4 after surgery were significantly different between the two groups(P0.05).The IgA and C3 on day 8 were significantly different between the two groups(P0.05).The CD3+,CD4+,and CD8+ of the control group,and the CD4+ and CD8+ of the experimental group were significantly different on day 1 before surgery,day 4 and day 8 after surgery(P0.05).The CD3+ and CD4+ of the control group,and the CD8+ of the experimental group were significantly different on day 1 before surgery and day 4 after surgery(P0.05).The CD3+,CD4+,CD8+,and CD4+/CD8+ on neither day 1 before surgery nor day 4 after surgery were significantly different between the two groups(P0.05).The CD4+,CD8+,and CD4+/CD8+ on day 8 were significantly different between the two groups(P0.05).Conclusion The IgA,C3,CD4+,CD8+,and CD4+/CD8+ of the experimental group on day 8 after surgery were significantly higher than those of the control group.Therefore,the Ala-Glu injection can significantly improve the post-operative immune function in patients with NSCLC.