Bromacil of the Original Observation of Drug Toxicity

To achieve the largest non-role of parameters for the safe production and chronic toxicity test to provide a reference dose,Subjects Bromacil were defined toxicity characteristics.We are based on GB15670-1995 registered pesticide toxicology test methodsof its 90 d toxicity test.Results:The average weeks weight of the high-dose group male rats from the second weeks to the end of the experiment was significantly lower than that of the control group(p0.05,p0.01),the WBC of the middle and high dose group male rats was significantly lower than that of the control group(p0.05),suggesting that subjects materials have some inhibitory effect on the WBC and the growth of male rats,the RBC and HGB of the high-dose group female rats was significantly lowerr than that of the control group(p0.01),The PLT,TG and GLU of the middle-dose group male,female rats was significantly lower than that of the control group(p0.01),prompted subjects materials have a certain influence on rat liver function and carbohydrate metabolism,organ weight results show that the kidney weight of the middle and high-dose group male rats and the high-dose group female rats was significantly higher than that of the control group(p0.01,p0.05),the liver weight of the middle and high dose group male and female rats was significantly higher than that of the control group(p0.01,p0.05),prompted the brain,the kidney,the liver and the spermary have been compensation function changes,the histopathological examination has not found organic changes and the dose group was no significant difference as compared with the control group.Conclusion:Bromacil male rats and female rats exposed to oral doses of 215 mg/kg bw.d and above,having the toxic effect on rats.Therefore,in this experiment,the largest no role dose of male and female was 107.50 mg/kg bw.d.Bromacil had an impacts on lipid and blood sugar metabolism.