Antimicrobial Activity of Piperacillin and Piperacillin-tazobactam against Enterobacteria in Vitro

Objective To investigate antimicrobial activity of Piperacillin and Piperacillin-tazobactam against enterobacteria in vitro. Methods Detection rates of escherichia coli and klebsiella pneumoniae in 29 539 clinical specimens during January 2011 and June 2013,and their resistance status against Piperacillin and Piperacillin-tazobactam were respectively analyzed. Results A total of 495 strains of klebsiella pneumoniae and 389 strains of escherichia coli were detected. When compared with that of Piperacillin,the sensitive rates of klebsiella pneumoniae and escherichia coli against Piperacillintazobactam were higher in the last 3 years,and the differences were statistically significant( P 0. 05); however,the sensitive rates of two bacteria to Piperacillin and Piperacillin-tazobactam showed downward trend in the last 3 years. Conclusion Tazobactam may enhance antibacterial activity of Piperacillin. However,for the sake of reducing nosocomial infection rate, Antibiotics therapy should choose synergistic drug combinations according to result of antibiotics susceptibility testing combined with resistance characteristics.