Clinical recommendation on paliperidone extended-release tablet in schizophrenia therapy

Schizophrenia is a group of disabling disorders with uncertain cause.Its course can be presented as one episode or span into a chronic state,ultimately requiring lifelong treatment.The treatment goals of schizophrenia are to rapidly control symptoms,and to gain a result of improved personal and social functioning.In this paper,clinical recommendation on paliperidone extended-release(ER) tablet in schizophrenia therapy was reviewed.Paliperidone ER is a recently developed atypical antipsychotic drug available for the treatment of schizophrenia.Paliperidone(9-hydroxy risperidone) is the major active metabolite of risperidone.By the unique extended-release delivery system,paliperidone ER can steadily deliver paliperidone and maintain steady plasma concentrations.It is efficacious in improving symptoms and social functioning of schizophrenia patients,and is well tolerated.