The study on antibacterial activity of amoxicillin sulbactam compared with other four antimicrobial agents in vitro

Aim To evaluate the antibacterial activity of Amoxicillin sulbactam compared with other four antimicrobial agents in vitro.Methods Amoxicillin sulbactam against clinical isolated strains were compared with amoxicillin,ampicillin sulbactam ,amoxicillin clavulanic acid and cefetaxime.Minimal Inhibitory Concentrations (MIC) were determined by use of agar dilution method.Results The susceptible rate of amoxicillin sulbactam against gram positive ball strains was 90.91%,higher than those of amoxicillin and cefetaxime.The susceptible rate of amoxicillin sulbactam against E.coli,Klebsiella pneumoniae and Hamophilas influenzae was 82.35% 83.3% and 100%,similar with those of amoxicillin clavulanic acid,ampicillin sulbactam and cefetaxime,higher than that of amoxicillin.The susceptible rate of amoxicillin sulbactam against Acinetobacter was 83.33%,higher than that of amoxicillin significantly,and better than other two agents containing β-lactamases inhibitors and cefetaxime.The antibacterial activity of amoxicillin sulbactam against common clinical isolates was better than that of amoxicillin,especially to β-lactamases positive strains.Conclusion Amoxicillin sulbactam is an effective antibiotic containing β-lactamases inhibitor and a powerful antimicrobial agents for clinical bacterial infection,especially to Acinetobacter.