Detection of Extended-spectrum Beta-lactamases and Analysis of Antibiotic Resistance in Clinical Isolates of Neonates with Lower Respiratory Tract Infection

Objective to explore the infection and the antibiotic resistance of extended-spectrum beta-lactamases (ESBLs) in the clinical isolates of Neonates with lower respiratory tract.Methods ESBLs producing strains were peformed by disk diffusion confirmation method,the antibiotic susceptibility test was peformed by Kirby-Bauer(K-B)disk diffusion method.Results ESBLs-producing strains had higher resistance rate than that of non-ESBLs-producing ones;ESBLs-producing strains were much higher resistant to ampicillin ,piperacillin,the combination of amoxicillin with clavulanic acid and third-generation cephalosporins,except ceftazidime ,the resistant rates were more than 80%;There were significant phenomenon in crossed antibiotic resistance.The susceptibility rate of all ESBLs-producing strains to imipenem was 100%.Conclusion The prevalence of ESBLs was high in clinical isolates of Neonates with lower respiratory tract infection;ESBLs-producing strains were the most sensitive to imipenem.Measures should be taken to control the infection of ESBLs-producing strains.