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Research advances in the detoxificating preparation of swainsonine in "locoweed" and its application to anti-tumor.

Baocheng Hao, Jianping Liang, Yang XianPeng, Yu Liu, Baohai Wang, Xuehong Wang, Jianzhi Liu, Meirong Zhao, Duo Zhang

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Abstract

Swainsonine was the main toxic component of locoweed,and belonged to polyhydroxyl-substituted indolizidine alkaloid.Swainsonine could inhibit α-mannosidase in animal body and poison both human and animals;it also had strong anti-tumor activity which was beneficial to human beings.The paper introduced the research advances in the biochemical characteristics,poisoning mechanism,detoxification preparation and anti-tumor function of swainsonine,aiming to provide references for preventing and curing swainsonine poisoning and rationally developing swainsonine.

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What this paper is about

Swainsonine was the main toxic component of locoweed,and belonged to polyhydroxyl-substituted indolizidine alkaloid.Swainsonine could inhibit α-mannosidase in animal body and poison both human and animals;it also had strong anti-tumor activity which was beneficial to human beings.The paper introduced the research advances in the biochemical characteristics,poisoning mechanism,detoxification preparation and anti-tumor function of swainsonine,aiming to provide references for preventing and curing swainsonine poisoning and rationally developing swainsonine.

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Available abstract

Swainsonine was the main toxic component of locoweed,and belonged to polyhydroxyl-substituted indolizidine alkaloid.Swainsonine could inhibit α-mannosidase in animal body and poison both human and animals;it also had strong anti-tumor activity which was beneficial to human beings.The paper introduced the research advances in the biochemical characteristics,poisoning mechanism,detoxification preparation and anti-tumor function of swainsonine,aiming to provide references for preventing and curing swainsonine poisoning and rationally developing swainsonine.

Key concepts: Swainsonine, Indolizidine, Detoxification (alternative medicine), Biology, Alkaloid, Chemistry, Biochemistry, Botany

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Research advances in the detoxificating preparation of swainsonine in "locoweed" and its application to anti-tumor. — Research Paper | ScholarLens