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The effect of β-glucan of cell wall from Candida albicans on interleukin-6 and interleukin-8 production by human peripheral blood mononuclear cells in vitro

Sun Jun

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Abstract

The levels of interleukin 6(IL 6) and IL 8 in the supernatant of human peripheral blood mononuclear cells(PBMC) stimulated by different concentration of alkali soluble and insoluble β glucan of cell wall from Candida albicans were detected by ELISA to investigate whether these two kinds of glucan could be capable of inducing PBMC cells to secret IL 6 and IL 8. The results showed IL 6 and IL 8 could be induced by 3 concentrations of insoluble β glucan, but alkali soluble β glucan could not induce these two cytokines at any concentration.

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What this paper is about

The levels of interleukin 6(IL 6) and IL 8 in the supernatant of human peripheral blood mononuclear cells(PBMC) stimulated by different concentration of alkali soluble and insoluble β glucan of cell wall from Candida albicans were detected by ELISA to investigate whether these two kinds of glucan could be capable of inducing PBMC cells to secret IL 6 and IL 8. The results showed IL 6 and IL 8 could be induced by 3 concentrations of insoluble β glucan, but alkali soluble β glucan could not induce these two cytokines at any concentration.

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Available abstract

The levels of interleukin 6(IL 6) and IL 8 in the supernatant of human peripheral blood mononuclear cells(PBMC) stimulated by different concentration of alkali soluble and insoluble β glucan of cell wall from Candida albicans were detected by ELISA to investigate whether these two kinds of glucan could be capable of inducing PBMC cells to secret IL 6 and IL 8. The results showed IL 6 and IL 8 could be induced by 3 concentrations of insoluble β glucan, but alkali soluble β glucan could not induce these two cytokines at any concentration.

Key concepts: Peripheral blood mononuclear cell, Candida albicans, Interleukin, Glucan, In vitro, Chemistry, Cytokine, Interleukin 2

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The effect of β-glucan of cell wall from Candida albicans on interleukin-6 and interleukin-8 production by human peripheral blood mononuclear cells in vitro — Research Paper | ScholarLens