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The Effect of PTEN on Genetic Stability

Wu Dechang

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Abstract

It is recently reported that tumor suppressor pten,encoding a protein and lipid phosphatase,plays a critical role in maintaining chromosomal integrity and genetic stability through phosphatase-dependent pathway as well as phosphatase-independent pathway.The mechanism of phosphatase-dependent pathway works mainly via PI3K/AKT way and the mechanism of phosphatase-independent pathway is mainly via interaction between proteins.In addition,there are still some pathways which have not been identified.

About this research paper

What this paper is about

It is recently reported that tumor suppressor pten,encoding a protein and lipid phosphatase,plays a critical role in maintaining chromosomal integrity and genetic stability through phosphatase-dependent pathway as well as phosphatase-independent pathway.The mechanism of phosphatase-dependent pathway works mainly via PI3K/AKT way and the mechanism of phosphatase-independent pathway is mainly via interaction between proteins.In addition,there are still some pathways which have not been identified.

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Available abstract

It is recently reported that tumor suppressor pten,encoding a protein and lipid phosphatase,plays a critical role in maintaining chromosomal integrity and genetic stability through phosphatase-dependent pathway as well as phosphatase-independent pathway.The mechanism of phosphatase-dependent pathway works mainly via PI3K/AKT way and the mechanism of phosphatase-independent pathway is mainly via interaction between proteins.In addition,there are still some pathways which have not been identified.

Key concepts: PTEN, Phosphatase, Protein phosphatase 2, Suppressor, PI3K/AKT/mTOR pathway, Tensin, Biology, Mechanism (biology)

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