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2007•Acta Academiae Medicinae WeifangRequires access

Relationship Between Expression of Matrix Metalloproteinase-2 and Clinical Pathology in Glioma

Zhen Zhang

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Abstract

Objective To explore the relation between expression of matrix metallop roteinase-2(MMP-2) and malignancy in glioma.Methods The expression of MMP-2 in 10 cases of normal brain tissues and 45 cases of glioma were detected by immunohistochemical streptavidin-peroxidase technique.The positive cells of MMP-2 were examined under binocular light microscope.Results ①The positive expression of MMP-2 in glioma was located in the tumor cytoplasm and endothelial cells.②The positive rates of MMP-2 in glioma of gradesⅠ、Ⅱ、Ⅲ and IV were 65.0%,86.7% and 100.0%.The expression of MMP-2 was correlated with glioma malignancy(r=0.627,P0.05).Conclusions The expression of MMP-2 is correlated with glioma malignancy,which may be helpful in judging the malignancy,invasion and prognosis of glioma.

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What this paper is about

Objective To explore the relation between expression of matrix metallop roteinase-2(MMP-2) and malignancy in glioma.Methods The expression of MMP-2 in 10 cases of normal brain tissues and 45 cases of glioma were detected by immunohistochemical streptavidin-peroxidase technique.The positive cells of MMP-2 were examined under binocular light microscope.Results ①The positive expression of MMP-2 in glioma was located in the tumor cytoplasm and endothelial cells.②The positive rates of MMP-2 in glioma of gradesⅠ、Ⅱ、Ⅲ and IV were 65.0%,86.7% and 100.0%.The expression of MMP-2 was correlated with glioma malignancy(r=0.627,P0.05).Conclusions The expression of MMP-2 is correlated with glioma malignancy,which may be helpful in judging the malignancy,invasion and prognosis of glioma.

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Available abstract

Objective To explore the relation between expression of matrix metallop roteinase-2(MMP-2) and malignancy in glioma.Methods The expression of MMP-2 in 10 cases of normal brain tissues and 45 cases of glioma were detected by immunohistochemical streptavidin-peroxidase technique.The positive cells of MMP-2 were examined under binocular light microscope.Results ①The positive expression of MMP-2 in glioma was located in the tumor cytoplasm and endothelial cells.②The positive rates of MMP-2 in glioma of gradesⅠ、Ⅱ、Ⅲ and IV were 65.0%,86.7% and 100.0%.The expression of MMP-2 was correlated with glioma malignancy(r=0.627,P0.05).Conclusions The expression of MMP-2 is correlated with glioma malignancy,which may be helpful in judging the malignancy,invasion and prognosis of glioma.

Key concepts: Glioma, Malignancy, Immunohistochemistry, Pathology, Matrix metalloproteinase, Medicine, Matrix metalloproteinase 9, Cancer research

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