Analysis of the reasons of abnormal circadian blood pressure in patients with hypertension

Objective To explore the reasons of abnormal circadian blood pressure in patients with hypertension.Methods Based on ambulatory blood pressure monitoring,452 patients with essential hypertension were grouped according to nocturnal blood pressure fall rate,fall rate 20% for the ultra-dipper hypertension,10% ≤ fall rate≤ 20% for the dipper group,0 ≤ fall rate 10% for the non-dipper group,fall rate 0 for the anti-dipper group.And we collect laboratory results and clinical data,and then analyze the correlation between abnormal blood pressure rhythm and target organ damage and the reasons of abnormal circadian blood pressure in patients with hypertension.Results The ages in the group of dipper,non-dipper and anti-dipper were 62.4±14.0 years old,66.0±14.5 years old and 70.7±11.3 years old,respectively,and the difference was statistically significant.The incidence of stroke in non-dippers was 27.6%,the difference was statistically significant when compared with the incidence in dippers;the incidence of coronary heart disease and stroke in anti-dipper were 52.8% and 32.8%,respectively,and the difference was statistically significant when compared with those in the dipper.Logistic regression shows that old age,increase of BMI and elevation of creatine were associated with anti-dippers.Conclusion Age,increasing of BMI and elevation of creatine may be involved in the formation of anti-dipper blood pressure rhythm.