Comparison of clinical efficacy of laparoscopic and open radical resection for colorectal cancer

Objective To investigate the safety and feasibility of laparoscopic radical resection for colonic and upper / median rectal cancer , and compare the short and long-term clinical efficacy of laparoscopic and open operations. Methods Clinicopathological data of 196 colorectal cancer patients undergoing laparoscopic (n=120) and open (n=76) radical resection in our hospital from January 2006 to December 2011 were analyzed retrospectively. The perioperative clinicopathological characteristics , postoperative complications and survival time were compared between the two groups. Results There were no significant differences in age and gender between the two groups. The operating time in the laparoscopic group was (226.28±61.09)min, significantly longer than (193.50±53.79)min in the open group. The blood loss was (84.00±28.41)ml in the laparoscopic group , significantly less than (187.60± 37.27)ml in the open group. The postoperative hospital stay was (7.55±2.04)d in the laparoscopic group, significantly shorter than (8.40 ±3.39)d in the open group. There were no significant differences in proximal and distal incision margin,number of dissected lymph nodes,and postoperative complications between the two groups. The 3- and 5-year survival rates were 76.6% and 71.2% in the laparoscopic group, 76.8% and 65.7% in the open group (P0.05). There were no significant differences in survivals of the patients with Duke’s A, B,C stages respectively between the two groups. Conclusions Laparoscopic radical resection for colorectal cancer is feasible and safe with less blood loss ,shorter hospital stay,rapid recovery.Furthermore,as for oncological safety,postoperative complications,and short and long-term efficacy, laparoscopical resection is not worse than open resection.