Relationship between screening of gestation specific hypothyroidism and pregnancy outcome

【Objective】To get the hypothyroidism,subclinical hypothyroidism and low T4 hyperlipidemia rate of the trimester-specific normal childbearing-age-women who lived in Changzhou.【Methods】Both gestational age specific reference intervals and population based reference intervals of thyroid function were applied to screening the hypothyroidism.The survey object were 1 971 pregnant women and there are 446 in the T1 stage(4～12 W),684 in the T2 stage(12～28 W),841 in the T3 stage(28～40 W) among the total.Thyroid-stimulating hormone(TSH),the free T4(FT4) and the autoantibodies against TPO(TPOAb) were measured by chemistry radiation method.Pregnancy outcome was followed-up using the medical record.【Results】In the T1,T2,T3 period of pregnant women,the case rate of clinical hypothyroidism was 0.45%,0.15%,0%.The case rate of subclinical hypothyroidism was 2.69%,3.07%,5.11%,the case rate of low T4 hyperlipidemia respectively were 1.79%,2.34%,2.02%.On the basis of non-pregnant reference range,the missed diagnosis rates of hypothyroidism,subclinical hypothyroidism and low T4 hyperlipidemia was 0.22%,1.79%,0.67% respectively.The adverse pregnancy outcome rate of subclinical hypothyroidism and low T4 hyperlipidemia was 57.89%,51.22% respectively,being significantly higher than normal thyroid function group,which were 18.78%(P 0.01).【Conclusion】It's necessity to screen hypothyroidism,according to gestational age specific reference intervals;Hypothyroidism,and its related thyroid abnormalities are associated with the complication such as gestational hypertension.