Analysis of Relevant Factors Causing Tracheal Stenosis Post-Trachectomy for Mechanical Ventilation in Adult

[Objective] To investigate the clinical relevant factors causing tracheal stenosis after trachectomy for mechanical ventilation in adult. [Methods] A retrospective study was carried out to review the history of clinical data from 246 patients who were performed trachectomy for mechanical ventilation in The First Affiliated Hospital of Sun Yat-sen University from 1994 to 2003. we analyzed the 11 clinical relevant factors causing tracheal stenosis including sex, age, intubation preoperative, intubation time preoperative, duration of mechanical ventilate postoperative, previous trachectomy, multiple change tube, cricothyroidotomy, recurrent airway infection, diabetes, gastroesophageal reflux, etc. Univariate x~2 test and multivariate stepwise logistic regression model were used for the analysis. [Results] Twenty-eight cases (11.4%) presented tracheal stenosis in 246 patients after trachectomy. In univariate analysis, it was confirmed that the following variables correlated to tracheal stenosis: intubation time preoperative (P=0.025), duration of mechanical ventilation postoperative (P=0.02), recurrent airway infection (P＜0.001), history of diabetes (P＜0.001), gastroesophageal reflux (P=0.026). In multivariate analysis, the significant risky factors for tracheal stenosis were duration of mechanical ventilation postoperative, history of diabetes, recurrent airway infection, gastroesophageal reflux. [Conclusion] The clinical relevant factors causing tracheal stenosis post-trachectomy for mechanical ventilation were various. Statistical analysis showed that duration of mechanical ventilation postoperative, recurrent airway infection, gastroesophageal reflux and history of diabetes were main risky factors which may cause tracheal stenosis.