Significance of Serum CA125 in Monitoring Efficiency and Recurrence of Advanced Overian Cancer

Objective To evaluate the value of serum CA125 as a marker in monitoring efficiency and recurrence of advanced ovarian cancer.Method ES300 automatic enzyme immune analysis system was used to detect the levels of serum CA125 in 54 stages Ⅲ and Ⅳ primary ovarian cancer patients,42 follow up ovarian cancer patients,24 recurrent or metastatic patients,15 cases of benign ovarian tumors and 65 healthy control women.Results (1)Pretreatment Serum CA125 levels in 54 advanced ovarian cancer patients were significantly higher than those in control group and ovarian benign tumors.Put 35 U/ml as critical value,CA125 levels were elevated in 100%(43/43) of epithelial ovarian cancer,and in 81.8%(9/11) of non epithelial ovarian cancer.There was no significant difference between stages Ⅲ and Ⅳ.(2)Serum CA125 levels decreased sharply after comprehensive therapy.The course of disease significantly correlated with the decrease range of serum CA125 after treatment,but did not correlate with the level before treatment.(3)In 42 follow up patients without recurrence,102 times serum CA125 detection were carried out,there are only 2 patients whose serum CA125 increased in two series assays.Otherwise,serum CA125 increased over 35U/ml in 23/24(95.8%) of patients with recurrent or metastatic diseases.Diagnosis rate of CA125 for recurrent or metastatic diseases were up to 95.4(63/66).Conclusions Series detection of serum CA125 is a useful index for evaluation of efficiency,recurrence,metastasis and prognosis.