Epidemiological analysis of pathogenic detection result of HFMD cases in Ningbo,Zhejiang province,China

Objective:To investigate epidemiological features of the pathogen of HFMD in Ningbo,which may provide reference for preventing and controlling the HFMD.Methods: 446 samples were collected from clinically diagnosed cases with HFMD,real-time quantitative RT-PCR or RT-PCR were carried out for nucleinic acid identification and typing.Results: Among the 446 clinical samples,346(77.58%)cases were tested positive,the proportion of male and female in the cases of HFMD was 2.035∶ 1.The peak of HFMD was in late spring and early summer.There were 191 cases of EV71 positive;121 cases of CoxA16 positive;13 cases of CoxA6 positive;7 cases of CoxA10 positive;4 cases of CoxA12 and ECHO9 positive;2 cases of CoxA2 positive;1 cases of CoxA4、CoxB1、CoxB4 and other enterovirus positive.EV71 was the dominant pathogen of the HFMD in Ningbo in 2009-2010(P0.05).Conclusion: The HFMD was mainly caused by EV71(55.20%)and CoxA16(34.98%)in Ningbo and showed characteristics of diversified and complicated.EV71 was the major enterovirus causing HFMD severe cases.