Relationship between MTHFR gene polymorphisms and susceptibility of esophageal cancer of Han nationality in Xinjiang

Objective To determine the association of 5,10-methylenetetrahydrofolate reductase(MTHFR) polymorphisms with the susceptibility of esophageal cancer in Han nationality in Xinjiang.Methods A case-control study was conducted.The polymorphisms of MTHFR gene at rs3753582,rs1801131,rs11121832,rs9651118,rs13306553,rs1801133 and rs13306561 were analyzed by polymerase chain reaction-ligase detection reaction(PCR-LDR) methods in 107 esophageal cancer cases and 204 non-cancer controls.Results The genotypes of MTHFR gene rs9651118 and rs1801133 had significant between cases and controls(χ2 =3.89,P=0.049;χ2=9.99,P=0.007).The subjects with rs9651118 position C allele had a decreased risk of esophageal cancer(OR=0.59,OR95%CI:0.36～0.99).There was a 2.21-fold(95%CI:1.05～4.69) increased risk of esophageal cancer in subjects with rs9651118 CT genotype compared with those carrying CC genotype,and there was a 3.45-fold(95%CI: 1.59～7.48) increased risk of esophageal cancer in subjects with rs9651118 TT genotype compared with those carrying CC genotype.The subjects with rs9651118 TT genotype and rs1801133 CT+TT genotype had a 3.55-fold(95%CI:1.38～9.13) increased risk of esophageal cancer.Conclusion MTHFR gene rs9651118T/C and rs9651118C/T polymorphisms are likely to be associated with the susceptibility to esophageal cancer.