2004•PubMedRequires access

[Effects of finasteride on capillary in the ventral prostate of rat].

Xiaodong Liu, Hong Li, Hong Bu, Yiping Lu, Qiang Wei, Ming Jun Shi, Zong-fu Chen, Yu-ru Yang

Abstract

OBJECTIVE: To investigate the effects of finasteride on capillary in the ventral prostate of rat and study the mechanisms therein involved, METHODS: Male SD rats were given via gavage finasteride 40 mg/kg per day for 7 days (group B) and for 14 days (group C). The changes of capillary infused with Chinese ink were observed with the use of HE staining. Immunohistochemical (IHC) SP-method was adopted in measuring the protein expression of VEGF and eNOS in rat prostatic tissue. RESULTS: In comparison with the relevant values measured in the control group (group A), the microvessel density (MVD) values in group B and group C decreased by 35.2% and 56% respectively, the protein expression of VEGF in group B and group C decreased by 31.7% and 62.6% respectively, the protein expression of eNOS in group B and group C decreased by 15.7% and 52.5% respectively. CONCLUSION: Finasteride can inhibit the protein expression of VEGF and eNOS and thereby can suppress angiogenesis of capillary in the ventral prostate of rat.

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Key concepts: Finasteride, Enos, Prostate, Immunohistochemistry, Endocrinology, Angiogenesis, Internal medicine, Microvessel