2007•PubMedRequires access

[Effect of p53 gene knockout on cell migration].

Xiaowei Gong, Jie Wei, Yusheng Li, Weiwei Cheng, Xu Wang, Peng Deng, Yong Jiang

Abstract

OBJECTIVE: To investigate the role of p53 gene in serum-induced cell migration. METHODS: The effects of p53 knockout on serum-induced formation of lamellipodia and cell migration were observed using Transwell cell migration system. RESULTS: p53(+/+) cells developed lamellipodia upon serum stimulation and showed enhanced activity of cell migration, but these effects were not observed in p53 knockout cells after serum stimulation. CONCLUSION: p53 plays a role in serum-induced cell migration.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Lamellipodium, Cell migration, Cell, Stimulation, Knockout mouse, Gene knockout, Cell biology, Gene