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Microglia and inflammation in Alzheimer’s disease

Lei De-liang

Open publisher page 4 citations

Abstract

Accumulating data evidenced inflammation involved in Alzheimer’s disease (AD). Microglia, one of the main immune cells in central nerve system, was activated in inflammation with morphological changes from resting ramified to staffed and amoeboid cells. Moreover, toxic cytokines and inflammatory mediators were released, which exerted a series of influence on adjacent tissue. Inhibiting the microglia activation to attenuate inflammatory damage will be an important strategy to prevent the further deterioration in AD.

About this research paper

What this paper is about

Accumulating data evidenced inflammation involved in Alzheimer’s disease (AD). Microglia, one of the main immune cells in central nerve system, was activated in inflammation with morphological changes from resting ramified to staffed and amoeboid cells. Moreover, toxic cytokines and inflammatory mediators were released, which exerted a series of influence on adjacent tissue. Inhibiting the microglia activation to attenuate inflammatory damage will be an important strategy to prevent the further deterioration in AD.

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OpenAlex reports 4 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Accumulating data evidenced inflammation involved in Alzheimer’s disease (AD). Microglia, one of the main immune cells in central nerve system, was activated in inflammation with morphological changes from resting ramified to staffed and amoeboid cells. Moreover, toxic cytokines and inflammatory mediators were released, which exerted a series of influence on adjacent tissue. Inhibiting the microglia activation to attenuate inflammatory damage will be an important strategy to prevent the further deterioration in AD.

Key concepts: Microglia, Inflammation, Immune system, Neuroinflammation, Alzheimer's disease, Neuroscience, Disease, Immunology

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