Application of ~1H-MRS in Assessing Prognosis of Primary Intracranial Diffuse Large B-cell Lymphoma

Objective To evaluate the application value of 1H-MRS in assessing prognosis of primary intracranial diffuse large B-cell lymphoma(DLBCL) by comparing 1H-MRS with pathology result. Methods MRI features, 1H-MRS and pathology results of 11 intracranial DLBCL were retrospectively analyzed. Tumor location, appearance and signal were analyzed. Cho, Cr, NAA, NAA/Cr, Cho/Cr, Cho/NAA values of the tumor solid part and contralateral brain parenchyma were measured. Paired sample T test was used to compare the tumors and control brain parenchyma. Correlation of Cho and Ki-67 was analyzed with Spearman analysis. Results All 11 cases showed raised Cho, Cho/Cr and Cho/NAA, and decreased NAA, Cr and NAA/Cr. The statistical analysis demonstrated that all except Cr had statistical significance(P0.05) between tumor solid region and compared normal brain. Spearman correlation analysis showed positive correlation between Cho and the expression level of Ki-67(rs=0.627, P=0.039). Conclusion 1HMRS has played an important role in preoperative diagnosis of intracranial DLBCL, it also could be used as an useful tool for assessing prognosis.